Schematic summarizes the entire project concept, highlighting various aspects related to the major technical innovations employed throughout the project. 

Bone regeneration remains a clinical challenge, particularly in the treatment of traumatic injuries, complex fractures, and orthopedic defects where conventional therapies are often insufficient to restore native tissue structure and function. A major limitation of current bone tissue engineering strategies is the inability to replicate the hierarchical extracellular matrix, the dynamic biomechanical environment, and the electromechanical cues that regulate bone formation and remodeling. Emerging advances in three-dimensional nanostructured scaffolds and electrical stimulation provide promising avenues to address these limitations.

The RESBONREG project aims to design, fabricate, and characterize 3D hybrid nanofibrous biomaterial constructs that mimic the structural, functional, and mechanical properties of native bone tissue. By integrating biomimetic scaffold architectures with controlled electrical stimulation, the project seeks to enhance key cellular processes, including proliferation, differentiation, migration, adhesion, and growth factor secretion. Electrical stimulation is expected to accelerate bone tissue maturation, improve biomechanical performance, and enhance load-bearing capacity by modulating interactions between engineered scaffolds and native bone tissue and by inducing bioactive responses. Collectively, these strategies aim to accelerate the overall healing process.

Funding: WEAVE project funded by the Austrian Science Fund (FWF), the German Research Foundation (DFG) and the Czech Science Foundation (GACR); Lead: German Research Foundation